I have survived over 500 hours in PermaDeath by rigidly adhering to a few standard rules. With the latest expedition many new players are coming to PD, and I think these standards will ease some frustrations.

1. Bugs. Many avoid PD for this reason alone. But I have never seen any bug that instantly kills. That isn't what's happening. Unless a bug pops up that stops you from opening the menu and reloading your last save, a death caused by a bug is partially your fault. Should be an easy choice to lose a little progress vs your whole save. The moment something bugs and you fall through the floor for example, pause, reload last save. Saved.

2. Don't end your play session saving in a hazardous environment. Only end your play saving in a 100% safe place. Space Station is best.

3. NEVER leave your character unattended, no matter how safe your setting is. Even if you're just going to the bathroom real quick. It is not worth the risk. Reloading your save takes less time than starting from the beginning. Nuff said.

4. Play with a wired interface if possible. If all you have is wireless, you need to stay on top of your charge. Set a reminder alarm. All it takes is one disconnect while near a predator or monstrosity, and it's curtains for you.

5. Do not play while impaired in any way. One slip of judgement is unacceptably risky in space exploration.

6. Avoid planetary hostile threats at all costs until you have at least 3 S class exosuit shield upgrades, preferably 6.

7. Avoid extreme terrain environments and heights until you have an least 3 S class movement upgrades, preferably 6, and the jetpack recharge tech.

8. Avoid pirates until you have at least 3 S class starship shield upgrades and a stack of sodium nitrate or starshield batteries. You can call in a freighter or the anomaly to escape any scans.

9. Friends don't let friends use plasma launchers and geology cannons in PermaDeath. This one is unfortunate, but until the self-harm it inflicts is nerfed, they're far too dangerous. I'd rather spend a bit more time dealing with grouped targets, than risk death.

10. Whispering eggs have lured many travelers to their end with nought but the promise of a few measley nanites. Not worth it. The only time you should willingly engage the monstrosities is when a mission demands it, and even then DO NOT LEAVE THE ROOFTOP!

11. Never depart without checking your supplies. Oxygen, Ion Batteries, Sodium/Sodium Nitrate, Tritium, Condensed Carbon, Warp Cells, Launch Fuel, are all things you should never run out of.

12. If you're not sure if something is lethal, assume it is. I should do more testing with a dummy profile to determine all lethal threats. I can't find much info pertaining to what can kill you. I know lightning and meteors can hurt you, but how threatening they are I cant say for sure. That leads to the next rule.

13. STAY OUT OF EXTREME STORMS! If all you can manage is digging a hole and waiting it out, do it. Don't attempt enduring them until your exosuit tech is fully upgraded. And don't attempt it at all in extreme wind events, those twisters are particularly lethal even late game.

14. Rocket boots are dangerous! They can cause a lot of unintentional forward jetpack boosts. Best to upgrade jetpack tanks and exosuit shields before using them. You've been warned.

15. Be extremely cautious when using glitches. Especially aboard your freighter. Always weigh the rewards of a glitch against your entire save.

16. Do not engage sentinels without nearby cover. You need a fast escape in case something goes awry. Any building or base with rooms will do.

Those are all the tips that come to mind atm.

In PermaDeath you have to take things more seriously. Every decision could be life and death for your traveler. Immerse yourself and remember every choice can lose you everything. I think the game is most thrilling with those stakes and it really forces an immersive perspective. PermaDeath is the closest experience to what exploring the cosmos would be like for us. So I encourage people to try it. I realize its not for everyone, but once you get used to the risk, things will become a nice blend of relaxing beauty and thrilling danger.

Safe Travels.